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apalutamide will lower the level or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medication which are CYP3A4 substrates may end up in decrease exposure to these prescription drugs.Co-codamol is a mix analgesic that is mad